Dr. Jothydev completed his M.B.B.S and MD in Internal Medicine from Govt. Medical College, Trivandrum. While he was doing his MD in Internal medicine, he got selected by the State Public Service Commission and joined as Lecturer in Internal Medicine in the same hospital. He continued as the Assistant Professor of Medicine and was very popular among the students for his bedside teaching and lecture classes.
In 1997 he started private practice in a tiny consultation room at Lekshmy Nilayam, his house situated at Mudavanmugal, Trivandrum .While working in Trivandrum Medical College he was interviewed by a team of Doctors and Civic Leaders and was selected for setting up a Diabetes Centre in Trivandrum in association with the world famous Mayo Clinic, USA. He went for fellowship training at Mayo Clinic along with his wife Sunitha Jothydev and son Krishnadev Jothydev. In 2001 itself he had more than 3000 diabetic patients on tele- medicine follow up, and he was assisted by Miss. Jayasree Lally, who joined his clinical practice in the year 1997.