Posted on: 04/01/2016

 

Major advances seen in "non-small cell lung cancer" treatment

 

Small cell lung cancerNew study in mice has shown that cancers with Kirsten rat sarcoma viral oncogene homolog (KRAS)-related gene mutations might benefit from a triple therapy.

 

Although the most common type of lung cancer - non-small cell lung cancer (NSCLC) - has recently seen major treatment advances in some genetic subtypes, other subtypes continue to evade effective treatment.

 

Now, a new study in mice has shown that cancers with Kirsten rat sarcoma viral oncogene homolog (KRAS)-related gene mutations might benefit from a triple therapy with two experimental drugs plus radiation therapy. According to professor of Radiation Oncology at Thomas Jefferson University Bo Lu,  the study suggests that there is a possibility to identify non-small cell lung cancer patients who are likely to benefit most from this combination of therapies, although further research in human subjects is needed to confirm the finding.

 

In order to help make these resistant KRAS mutants more susceptible to therapy, the researchers combined the KRAS-targeting drug with another drug that would undo the effects of the p16 mutation. Currently, neither of two drugs that target KRAS and proteins in the p16 pathway has been approved for use in lung cancer but it is hopeful that this research will help identify the patients who could potentially benefit from a triple-therapy treatment.

 

The study is published in the Journal Clinical Cancer Research

To know more about the latest update on this treatment protocol and treating centers offering the same as well as for getting your reports reviewed, post a query

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