Links found between breast cancer drug and brain malfunction
A breast cancer drug shows side-effects such as mood disturbances and memory issues, which affect the functioning of brain in both humans and animals, according to researchers.
The drug called Letrozole is used to prevent the recurrence of breast cancer by interfering with estrogens production. However, researchers from the University of Toronto, Canada demonstrated that letrozole was administered to male and female marmosets for four weeks which led to many behavioural changes such as hot flashes and increased anxiety, as experienced by women receiving similar treatment.
Published in the Journal of Neuroscience, the results further revealed that letrozole also hampered the function of neurons in the hippocampus and weakened spatial memory.
According to the team, findings stress the need for further investigation of breast cancer treatments and their impact on the brain.
Breast cancer is the most common cancer in women worldwide and is increasing considerably in developing countries where most of the cases are diagnosed in advanced stages.
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